Endocrine Today has compiled a list of the top 10 menopause news reports posted in 2018. This year, Healio.com/Endocrinology readers were interested in osteoporosis therapies, fracture risk during drug holidays, FRAX and more.
Amgen, UCB resubmit biologic license application for romosozumab
Amgen and UCB have resubmitted a biologics license application to the FDA for romosozumab for the treatment of osteoporosis in postmenopausal women at high risk for fracture, according to a press release from both companies.
Higher carotenoid consumption associated with reduced hip fracture risk
Chinese adults who consume greater levels of carotenoids, including foods rich in beta-carotene, lycopene and lutein, are less likely to experience hip fracture vs. those with a diet that includes less of the antioxidants, according to findings from a case-control study.
Bone fracture risk rises during ‘drug holidays’
Approximately 15% of patients with osteoporosis who stop taking bisphosphonates experience bone fractures.
FRAX: A nuanced tool for predicting fracture risk
In the 1990s, as part of an increased focus on the burden of noncommunicable diseases, WHO identified osteoporosis as a future major health problem. To address this problem, researchers sought to create a tool designed to predict those at future risk for fragility fracture.
Large weight loss raises fragility fracture risk in type 2 diabetes
Adults with type 2 diabetes who lost at least 30% of their maximum body weight had increased risks for fragility fractures and any fracture compared with those who lost less weight.
Fracture incidence in thyroid cancer linked to levothyroxine dose
Adults with thyroid cancer taking less than 115 µg per day or at least 145 µg per day of levothyroxine after thyroidectomy or radioiodine ablation therapy had an increased risk for fractures compared with those taking 115 to 144 µg per day.
In search for ‘perfect’ osteoporosis treatment, consider key anti-aging mechanism
A fundamental aging mechanism that drives tissue dysfunction throughout the body may serve as a novel target in the treatment of osteoporosis, suggesting an exciting new pathway for researchers in a field where a “perfect” therapy has remained elusive.
Mobility exercises can reduce fall risk for older adults
Dual-task functional power and mobility training was shown to improve muscle power, reaction time and mobility and limit multiple falls for older adults.
Denosumab superior to bisphosphonate therapy for building BMD
The human monoclonal antibody denosumab more effectively increases bone mass in patients with low bone mineral density or osteoporosis when compared against any bisphosphonate therapy.
National Osteoporosis Foundation, Medtronic launch fracture prevention initiative
The National Osteoporosis Foundation and Medtronic are launching a joint partnership to educate clinicians and the public about vertebral compression fractures and available treatment options to increase positive health outcomes related to osteoporosis management, according to a press release.