The upper-limit intake for vitamin D recommended by the Endocrine Society, when coadministered with calcium intake at the upper recommended level, is associated with increased odds for hypercalciuria when compared against recommendations from the Institute of Medicine, according to findings from a randomized, double-blind controlled trial.

The 2011 Institute of Medicine (IOM) report recommends an upper limit of 4,000 IU per day for vitamin D and 2,000 mg per day for calcium for adults aged at least 51 years, whereas the Endocrine Society guideline on vitamin D, which followed the IOM report, recommends an upper limit of 10,000 IU vitamin D per day, based on the risk for hypercalcemia, John Aloia, MD, of the Bone Mineral Research Center at Winthrop University Hospital in Mineola, New York, and colleagues wrote in the study background.