Adrenal

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Glucocorticoid replacement doses tied to mortality risk in nonfunctioning pituitary adenoma

June 27, 2017

Patients with nonfunctioning pituitary adenoma who receive daily hydrocortisone replacement doses greater than 20 mg are at increased risk for death from any cause vs. similar patients receiving lower doses and those without secondary adrenal insufficiency, according to findings published in the European Journal of Endocrinology.

“The previously demonstrated excess mortality in patients with adrenal insufficiency has been mainly attributable to cardiovascular, respiratory and infectious diseases as well as cancer,” Daniel S. Olsson, MSc, MD, PhD, of the Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden, and colleagues wrote. “It is likely that the degree of adrenal insufficiency is of importance for outcome and that patients who are completely insufficient may be more vulnerable to intercurrent illness, whereas patients with partial [adrenocorticotropic hormone] deficiency may be overtreated under normal unstressed conditions using conventional replacement doses. Hence, inadequate treatment of hypocortisolism remains a significant cause of death during stressful events and intercurrent illness in patients with hypopituitarism.”

In the Journals Plus

Pheochromocytoma may reduce bone mass at the lumbar spine

June 7, 2017
Adults with pheochromocytoma had lower bone mass at the lumbar spine compared with adults with nonfunctional adrenal incidentaloma, according to recent study findings. …
In the Journals Plus

Consensus report defines outcomes criteria for surgery in unilateral primary aldosteronism

June 6, 2017
Younger patients and women with unilateral primary aldosteronism are more likely to experience a favorable outcome after total adrenalectomy than men or older patients…
In the Journals Plus

Androgen deprivation therapy fails to affect telomere length in prostate cancer

June 5, 2017
Men with nonmetastatic prostate cancer who received androgen deprivation therapy for 2 years saw no change in leukocyte telomere length when compared with controls who…
CME CNE CE CE

Diabetic Retinopathy: Preferred Practice Patterns in Screening and Management

This activity is supported by an educational grant from Regeneron.

Diabetic retinopathy (DR) is a major cause of blindness among American adults aged 40 years and older. The prevalence…
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Meeting News Coverage

Vlog: Global endocrinology community gathers for ICE/ENDO 2014

June 21, 2014
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The Endocrine Society Annual Meeting

The Endocrine Society Annual Meeting

CNE CME CPE

What You Need to Know About Familial Chylomicronemia Syndrome: Pathophysiology, Diagnosis, Management, and the Patient Perspective

This activity is supported by an educational grant from Akcea Therapeutics™ A Subsidiary of Ionis Pharmaceuticals, Inc.
Endorsed by: The National Lipid Association.

Familial chylomicronemia syndrome (FCS) is a rare genetic disease that leads to severe hypertriglyceridemia and…
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In the Journals Plus

Glucocorticoid replacement doses tied to mortality risk in nonfunctioning pituitary adenoma

June 27, 2017
Patients with nonfunctioning pituitary adenoma who receive daily hydrocortisone replacement doses greater than 20 mg are at increased risk for death…

In the Journals Plus

Pheochromocytoma may reduce bone mass at the lumbar spine

June 7, 2017
Adults with pheochromocytoma had lower bone mass at the lumbar spine compared with adults with nonfunctional adrenal incidentaloma, according to…

In the Journals Plus

Consensus report defines outcomes criteria for surgery in unilateral primary aldosteronism

June 6, 2017
Younger patients and women with unilateral primary aldosteronism are more likely to experience a favorable outcome after total adrenalectomy than men…

In the Journals Plus

Androgen deprivation therapy fails to affect telomere length in prostate cancer

June 5, 2017
Men with nonmetastatic prostate cancer who received androgen deprivation therapy for 2 years saw no change in leukocyte telomere length when compared…

In the Journals PlusPerspective

Primary aldosteronism incidence low in type 2 diabetes

May 18, 2017
The prevalence of primary aldosteronism among adults with type 2 diabetes is relatively low, but those with primary aldosteronism have higher…

In the Journals Plus

Health care expenditure burden high in adrenal insufficiency

April 21, 2017
Patients with adrenal insufficiency may accrue substantial health care costs and have more hospital stays and outpatient visits compared with healthy…

In the Journals Plus

Lower health-related quality of life observed in patients with Addison’s disease, Cushing’s syndrome

April 20, 2017
Patients with hypothalamic-pituitary-adrenal axis dysregulations report health-related quality of life that is far lower than that of the general…

Meeting News Coverage

Adrenal vein sampling, CT scanning yield similar outcomes in primary aldosteronism screening

April 7, 2017
ORLANDO, Fla. — As a screening method, adrenal vein sampling is a “brilliant concept” when used to identify primary aldosteronism…

Meeting News CoveragePerspective

New molecules may offer next-generation treatment in prostate cancer

April 5, 2017
ORLANDO, Fla. — Highly potent selective androgen receptor degraders, or SARDs, may provide advanced treatment options for men with…

Meeting News

Age at symptom onset tied to survival in adrenocortical carcinoma

April 3, 2017
ORLANDO, Fla. — Older age at adrenocortical carcinoma symptom onset and higher stage disease are independently associated with overall survival…

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