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Long-acting pasireotide safe, effective for recurrent Cushing’s disease

October 20, 2017

In patients with persistent or recurring Cushing’s disease after surgery, monthly pasireotide was safe and effective, leading to normal urinary free cortisol levels in about 40% of patients after 12 months, according to findings from a phase 3 clinical trial.

“Surgical resection of the causative pituitary adenoma is the first-line treatment of choice for most patients with Cushing’s disease, which leads to remission in greater than 75% of patients if done by an expert pituitary surgeon,” Andre Lacroix, MD, professor in the department of medicine at University of Montreal teaching hospital, and colleagues wrote in the study background. “However, surgery is not always successful, and disease recurrence can occur several years after initial remission, while some patients refuse or are not candidates for surgery. As a result, many patients require additional treatment options.”

In the Journals Plus

Salivary cortisol biomarker may improve glucocorticoid therapy management

October 5, 2017
In patients with adrenal insufficiency, salivary cortisol rhythm may serve as a useful biomarker to evaluate the adequacy of glucocorticoid replacement, according to…
In the Journals Plus

Primary aldosteronism may be cause behind secondary osteoporosis

August 14, 2017
Patients with secondary osteoporosis are 10 times more likely to have primary aldosteronism than patients without osteoporosis, according to findings from an Italian…
In the Journals Plus

Congenital adrenal hyperplasia often leads to impaired executive function

August 11, 2017
Adolescents and adults with congenital adrenal hyperplasia demonstrated normal psychometric intelligence but had impaired executive functions compared with controls…
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Early Treatment of Diabetic Retinopathy and Diabetic Macular Edema: Optimal Use of Anti-VEGF Therapy for Vision Preservation and Restoration

This activity is supported by an educational grant from Genentech, Inc.

Diabetic retinopathy (DR) and diabetic macular edema (DME) are 2 of the most common causes of blindness among…
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VIDEO: Late diagnosis of Cushing's disease still a problem

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Rapid Response from Austin: Expanding Options in Type 2 Diabetes Management

This activity is supported by educational grants from Boehringer Ingelheim Pharmaceuticals, Inc. and Lilly USA, LLC.

Approximately 150 million people worldwide have diabetes mellitus and this number is expected to double by 2025…
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