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CANTOS: Canakinumab reduces risk for major CV events in patients with MI, inflammatory atherosclerosis

June 22, 2017

Read the Perspective from Carl J. Pepine, MD, MACC

In patients with prior MI and inflammatory atherosclerosis, canakinumab in combination with standard-of-care therapy reduced risk for major adverse CV events, according to the topline results of the CANTOS study announced by Novartis.

According to a press release from Novartis, the phase III study of canakinumab, also known as ACZ885, met its primary endpoint of reduction in major adverse CV events, defined as CV death, nonfatal MI and nonfatal stroke. Median follow-up for the 10,061 patients in the study was 3.8 years.

In the Journals

Head position may not affect outcomes during acute stroke treatment

June 22, 2017
During treatment for acute stroke, whether a patient was lying down or sitting up did not make a difference in disability outcomes, according to a study in The New
In the Journals

Breast-feeding may lower risk for CVD, stroke

June 21, 2017
Women who breast-fed had a lower risk for CVD and stroke compared with women who never breast-fed, according to a study published in the Journal of the American Heart
Perspective

USPSTF recommends screening for obesity in children, adolescents

June 20, 2017
The U.S. Preventive Services Task Force recommends that clinicians screen for obesity in children and adolescents aged at least 6 years and offer or refer them to…
Perspective

CANTOS: Canakinumab reduces risk for major CV events in patients with MI, inflammatory atherosclerosis

June 22, 2017
In patients with prior MI and inflammatory atherosclerosis, canakinumab in combination with standard-of-care therapy reduced risk for major adverse…

In the Journals

Head position may not affect outcomes during acute stroke treatment

June 22, 2017
During treatment for acute stroke, whether a patient was lying down or sitting up did not make a difference in disability outcomes, according to a…

In the Journals

Breast-feeding may lower risk for CVD, stroke

June 21, 2017
Women who breast-fed had a lower risk for CVD and stroke compared with women who never breast-fed, according to a study published in the Journal of

Perspective

USPSTF recommends screening for obesity in children, adolescents

June 20, 2017
The U.S. Preventive Services Task Force recommends that clinicians screen for obesity in children and adolescents aged at least 6 years and offer or…

In the Journals

Racial disparities evident in risk factors for stroke

June 16, 2017
The risk for stroke decreased in the United States, but racial disparities still exist, according to a research letter in The New England Journal of

In the JournalsPerspective

Long-term aspirin use in older patients increases risk for major bleeding

June 14, 2017
Patients who had an MI, transient ischemic attack or ischemic stroke and received aspirin-based antiplatelet treatment without proton pump inhibitors…

In the Journals

Screening for AF in older adults may reduce mortality, stroke

June 8, 2017
Screening for atrial fibrillation in adults aged at least 65 years and treating with anticoagulants may reduce risk for stroke and death, according…

Feature

2 decades of stroke

Cardiology Today, June 2017
Editor’s Note: Cardiology Today is celebrating its 20th anniversary in 2017. We are reaching out to experts in cardiology for their take on

In the Journals

Direct oral anticoagulants may be underprescribed to patients with AF, high stroke risk

June 6, 2017
Direct oral anticoagulants increased the use of oral anticoagulation in patients with atrial fibrillation, but many eligible patients have not been…

In the Journals

Cirrhosis associated with increased risk for stroke, hemorrhagic stroke

June 5, 2017
Recently published data showed an association between cirrhosis and an increased risk for stroke, particularly hemorrhagic stroke, which may be…

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