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HYDRA: Rosuvastatin reduces LDL in children with homozygous FH

HYDRA: Rosuvastatin reduces LDL in children with homozygous FH
August 21, 2017

Children with homozygous familial hypercholesterolemia who were treated with rosuvastatin in addition to ezetimibe and/or apheresis reduced their LDL safely and effectively, according to a randomized, double blind crossover study published in the Journal of the American College of Cardiology.

Evan A. Stein, MD, PhD, director emeritus of the Metabolic and Atherosclerosis Research Center in Cincinnati, and colleagues analyzed data from 14 children (mean age, 11 years; 50% boys) with homozygous familial hypercholesterolemia (HoFH), 13 of whom completed the HYDRA study. A 4-week lead-in phase preceded the study, when patients discontinued all lipid-lowering therapies except apheresis (50%) and/or ezetimibe (57%) and received 10 mg rosuvastatin daily with dietary advice.

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