A. Severe mitral regurgitation from mitral valve prolapse in an asymptomatic patient when repair instead of replacement is anticipated
B. Severe mitral regurgitation causing severe systolic dysfunction and an ejection fraction of 20% regardless of the etiology
C. Acute severe mitral regurgitation from a rupture papillary muscle after an inferior myocardial infarction
D. Severe mitral regurgitation with normal left ventricular systolic function causing New York Heart Association functional class III symptoms
E. Asymptomatic severe mitral regurgitation with the left ventricular ejection fraction > 60% and end systolic dimension < 40 mm without atrial fibrillation or pulmonary hypertension.