6. What is the long-term complication of childhood Kawasaki’s disease?
Coronary aneurysms. When a coronary arterial wall becomes weakened it can dilate and form a coronary artery aneurysm. This can occur as post-stenotic dilation during ahteroslcerotic coronary disease or can occur as a part of a vasculitis. Kawasaki's disease (a form of vasculitis) during childhood can lead to coronary aneurysms in adulthood causing ischemic heart disease and angina. When the coronary aneurysms are large. the pathophysiologic mechanism of ischemia is thought to be due to microemboli and thus anticoagulation with warfarin is frequently utilized although there is no clinical data to support this therapy.