Summary: Randomized patients with unstable angina and non-ST elevation MI (NSTEMI) who were not going to undergo percutaneous coronary intervention (PCI) to prasugrel or clopidogrel. The primary endpoint of composite death from cardiovascular causes nonfatal MI or nonfatal stroke in those under age 75 was no different in the two groups. There was no difference in major bleeding, however minor bleeding was higher with prasugrel.

Original Publication:

N Engl J Med. 2012 Aug 25.

Eponym: TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes