Summary: Evaluated nitrendipine with and without enalapril and/or hydrochlorothiazide versus placebo in patients with hypertension. The primary endpoint of fatal and nonfatal stroke was reduced by 42%. Composite cardiac endpoint was reduced by 26%.

Original Publication:

Lancet. 1997 Sep 13;350(9080):757-64.

JAMA. 1999 Aug 11;282(6):539-46.

Eponym: Systolic Hypertension In Europe