Summary: Evaluated implantable cardioverter defibrillators (ICDs) versus amiodarone versus placebo in patients with New York Heart Association functional class II or III systolic heart failure with ejection fractions < 35%. ICD implantation reduced mortality (relative risk reduction 23%). Amiodarone had no mortality benefit.

Original Publication:

N Engl J Med. 2005 Jan 20;352(3):225-37.

Eponym: Sudden Cardiac Death in Heart Failure Trial