Summary: Evaluated aggressive rate control in permanent atrial fibrillation (heart rate goal < 80 beats per minute) versus less aggressive rate control (heart rate goal < 110 beats per minute). There was no difference in the primary endpoint of death from cardiovascular causes, hospitalization for heart failure, stroke, systemic embolization, bleeding and life-threatening arrhythmic events in the two groups. There were fewer clinic visits in the less aggressive rate control group.
N Engl J Med. 2010 Apr 15;362(15):1363-73. Epub 2010 Mar 15.
Eponym: RAte Control Efficacy in permanent atrial fibrillation