Summary: Evaluated transcatheter aortic valve replacement (TAVR or TAVI) versus standard surgical aortic valve replacement. The primary endpoint of all-cause mortality was the same in both groups. Symptoms and stroke risk the same. There was a decrease in mortality in a subgroup of patients who were not candidates for surgical intervention, but underwent TAVR.

Original Publications:

N Engl J Med. 2011 Jun 9;364(23):2187-98.

N Engl J Med. 2012 Mar 26.

N Engl J Med. 2010 Oct 21;363(17):1597-607.

N Engl J Med. 2012 Mar 26.

Eponym: The Placement of AoRTic TraNscathetER Valve Trial