FAME Trial

Summary: Evaluated using fractional flow reserve (FFR) guided percutaneous coronary intervention (PCI) versus standard therapy in patients with at least 2 stenosis of 50% or greater in major coronary vessels. The primary composite endpoint of all-cause mortality, nonfatal MI or coronary artery bypass grafting or repeat PCI was significantly reduced in the FFR guided PCI group.

Original Publication:

N Engl J Med. 2009 Jan 15

Eponym: Fractional Flow Reserve Versus Angiography for Multivessel Evaluation Trail