Summary: Evaluated ezetimibe with simvastatin versus simvastatin alone in patients with familial hypercholesterolemia. The primary endpoint of change in mean carotid-artery intima media thickness was not changed with ezetimibe. LDL was reduced further by ezetimibe. This is not a clinical endpoint trial. Carotid intima media thickness is thought to be a surrogate for atherosclerotic heart and vascular disease.

Original Publication:

N Engl J Med. 2008 Apr 3;358(14):1431-43.

Eponym: Ezetimibe and Simvastatin in Hypercholesterolemia ENHANCEs Atherosclerosis Regression Trial