Acronym: Diabetes and Insulin-Glucose infusion in Acute Myocardial Infarction
Purpose: To determine if strict control of glocuse levels in diabetic patients during acute coronary syndromes improves outcomes.
Format: Double-blind, multicenter, randomized control trial
Treatment Group: Insulin IV infusion (insulin drip) followed by subcutanous insulin
Control Group: Routine diabetes therapy
Number of Patients: 620
Suspected acute coronary syndrome within 24 hours
Blood glucose > 11 mm/L (even if formal diabetes diagnosis not present)
Refusal to participate
Follow-up: Average of 3.4 years
Primary Endpoint: All-cause mortality
Secondary Endpoint: None
Evaluated intensive glucose control in diabetic patients with acute coronary syndromes. There was a reduction in long-term mortality in the intensive treatment group. This was not reproduced in the DIGAMI 2 trial.
Malmberg K, et al. Circulation. 1999;doi:10.1161/01.CIR.99.20.2626.