Acronym: Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
Format: Randomized, multi-center comparison
Treatment group 1: Cardioversion and rhythmn-control therapy
Treatment group 2: Rate-control therapy
Number of patients: 4,060
Primary endpoint: Overall mortality
Evaluated a rate control vs. a rhythm control strategy in patients with atrial fibrillation. The composite endpoint of death from cardiovascular causes, heart failure, thromboembolic complications, bleeding, need for pacemaker and adverse reaction to antiarrhythmic drugs was not different in the two groups. Subanalysis showed increased mortality for rhythm control strategy in the elderly, coronary disease patients and systolic heart failure patients. Anticoagulation was recommended for all patients as thromboembolic risk was similar in the two groups, even if rhythm control strategy was undertaken.
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