Among adults with obesity, each 1-standard deviation increase in BMI increases the odds for type 2 diabetes by 67% and for coronary artery disease by 20%, according to a meta-analysis of Mendelian randomization studies published in JAMA Network Open.
“For a long time, it was debatable whether obesity causes CAD or not,” Haitham Ahmed, MD, MPH, FACC, a preventive cardiologist with Cleveland Clinic, told Endocrine Today. “Many researchers felt there was an ‘obesity paradox’ in clinical studies and wondered whether it was confounders (such as hyperlipidemia or hypertension) that were causing the CAD rather than the obesity itself. We could not do randomized controlled trials to answer the question because it is unethical and unfeasible to randomize one group to become obese and another to stay lean. The next best thing is to do Mendelian randomization, which is nature’s randomized trial.”
This educational activity is supported by an educational grant from Amarin Pharma Inc.
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