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DEVOTE: Insulin degludec demonstrates CV safety, reduced risk for severe hypoglycemia

DEVOTE: Insulin degludec demonstrates CV safety, reduced risk for severe hypoglycemia
June 21, 2017

SAN DIEGO — In the DEVOTE cardiovascular outcomes trial, insulin degludec was noninferior to insulin glargine for the primary endpoint of major adverse cardiovascular events and was associated with significant reductions in severe hypoglycemia among high-risk patients with type 2 diabetes.

The randomized, double blind, treat-to-target, event-driven, CV outcomes trial included 7,637 patients with type 2 diabetes enrolled at 436 sites in 20 countries between October 2013 and November 2014. Researchers randomly assigned 3,818 patients to receive insulin degludec 100 U/mL (Tresiba, Novo Nordisk), a new-generation, ultra-long-acting basal insulin, and 3,819 to receive insulin glargine U100 (Lantus, Sanofi), a first-generation insulin, once per day between dinner and bedtime.

Perspective

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Low vitamin D level predicts CV morbidity, mortality in type 2 diabetes

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Diabetes management among Latino patients begins with language-concordant care

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Pioglitazone reduces major adverse CV events in prediabetes, diabetes

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High deductibles may lead to increased diabetes complications

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Patients with diabetes who have low-incomes and health savings account–eligible high-deductible health plans experienced significant increases…

Q&A: American Diabetes Association's updated standards

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The American Diabetes Association recently updated its Standards of Medical Care in Diabetes to underscore new drug recommendations for patients…

In the Journals

High-, low-deductible plans linked to higher out-of-pocket spending among chronically ill adults

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Americans with chronic conditions who had high- or low-deductible health insurance plans also had higher out-of-pocket spending and more frequent

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Pharmacy CV screening may benefit patients with suspected AF

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Integrated CV screening identified patients who could potentially benefit from stroke prevention therapies due to presence of atrial fibrillation…

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Parathyroid hormone associated with arterial stiffness in type 1 diabetes

January 10, 2017
In adults with type 1 diabetes, a higher level of parathyroid hormone is associated with increased arterial stiffness, a strong predictor of…

CommentaryPerspective

2016: An active, exciting year in cardiology

Cardiology Today, January 2017
Carl J. Pepine, MD, MACC
The past year has been a very active and exciting one in CVD and CV medicine. We have had major successes on several fronts. Not only was this true…

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