SAN FRANCISCO — Sanjit S. Jolly, MD, MSc, of McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada offers investigator insight on the 1-year results from the TOTAL trial.
Jolly provides background on the research, citing a standing belief by practitioners with regard to thrombus aspiration following the TAPAS trial that was “almost like a religion,” and outlines the aims and outcomes of the significantly larger TOTAL trial that included more than 10,000 patients.
He details the dashed hopes and lessons learned, including the “need to be careful of small trials, especially small trials that change practice where we actually don’t know the truth.”
He underscores the importance of large trials questioning established practice and highlights opportunities where the approach might be used other than as a routine strategy.
“As a clinician, I’m very happy to have this new information,” Jolly said. “It’s very important for both patients and us.”