Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 13: Is There Ever A Time To Switch To 5-Aminosalicylic Acids In Ulcerative Colitis? (continued)

Stephen B. Hanauer, MD

Reasons to switch to 5-aminosalicylic acid (5-ASA) agents are as follows: There are several times to switch the 5-ASAs administered in ulcerative colitis (UC). Considering that 5-ASAs are the main “foundational” therapies for mild to moderately active disease and for maintaining remissions, it is important to understand the different delivery systems, dosing, and potential side effects. Despite the variety of oral 5-ASA formulations (azo-bond, pH-dependent, and delayed-delivery), there does not appear to be a substantial difference in efficacy between oral formulations when…