Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 29: My Patient Has Primary Sclerosing Cholangitis And Ulcerative Colitis. Is There A Role For Ursodeoxycholic Acid Anymore? (continued)

Elizabeth J. Carey, MD; Keith D. Lindor, MD

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, likely immune mediated, characterized by chronic inflammation of the intrahepatic and extrahepatic bile ducts. Over time, progressive inflammation and subsequent fibrosis of the biliary tree lead to cirrhosis and its attendant complications: portal hypertension, synthetic dysfunction, and ultimately death or the need for liver transplantation. Even in the absence of hepatic dysfunction, patients with PSC have impaired quality of life with frequent bouts of jaundice and cholangitis. Approximately 80% of patients…