Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 14: Current and Future Topical Mesalamine Derivatives in Ulcerative Colitis (continued)

Jeffrey W. Nathanson, MD; Russell D. Cohen, MD

CURRENT AND FUTURE TOPICAL MESALAMINE DERIVATIVES IN ULCERATIVE COLITIS Sulfasalazine has been used in the treatment of ulcerative colitis (UC) for more than 50 years. In 1977, Khan et al demonstrated that mesalamine (also referred to as mesalazine or 5-ASA) was the therapeutically active component of sulfasalazine.1 Since then, a number of different mesalamine derivatives have been developed, each with its own specific delivery system. Topical formulations of mesalamine offer several unique advantages as a means of drug delivery. More than two-thirds of all patients with UC have endoscopic…