Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 21: Calcineurin Inhibitors (Cyclosporine, Tacrolimus, Sirolimus) and Mycophenolate Mofetil Use in Ulcerative Colitis (continued)

Hans Herfarth, MD, PhD; Jürgen Schölmerich, MD, PhD

CALCINEURIN INHIBITORS (CYCLOSPORINE, TACROLIMUS, SIROLIMUS) AND MYCOPHENOLATE MOFETIL USE IN ULCERATIVE COLITIS Immunomodulatory therapies with the calcineurin inhibitors cyclosporine and, more recently, tacrolimus play an important role in the management of patients with severe, steroid-refractory or steroid-dependent ulcerative colitis. Sirolimus, another inhibitor of calcineurin, and a potential alternative drug, mycophenolate mofetil, may be appropriate therapeutic options for the treatment of patients with severe ulcerative colitis. Currently, there is inadequate published controlled…