Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 16: Oral and Parenteral Corticosteroids in Ulcerative Colitis (continued)

Leonard Baidoo, MD; Gary R. Lichtenstein, MD, FACP, FACG, AGAF

ORAL AND PARENTERAL CORTICOSTEROIDS IN ULCERATIVE COLITIS The etiology of ulcerative colitis remains elusive; however, it is perceived that the complex interaction of environmental, genetic, and immunologic factors play a role in its pathogenesis.1 Medications that target immunoinflammatory pathways are effective in the treatment of patients with UC. Since 1955, corticosteroids have been demonstrated to be effective for the treatment and rapid relief of symptoms in patients with UC,2 subsequent to its mechanism of action on the immunoinflammatory pathways. Corticosteroids produce consistent…