Clinical Challenges and Complications of IBD

Miguel D Regueiro, MD; Jason Swoger, MD MPH

Chapter 4: Toxic Ulcerative Colitis And Megacolon (continued)

Garret Cullen, MD; Adam S. Cheifetz, MD

Ulcerative colitis (UC) is a chronic inflammatory disease characterized by acute flares of activity between periods of remission. Approximately 15% of patients with UC will develop an acute severe flare over the lifetime of their disease.1 Ten percent of patients with UC develop an acute severe flare as their initial presentation of the disease.2,3 Confirmation of the diagnosis on admission is essential and includes a good history, physical examination, laboratory markers, and imaging of the abdomen (to rule out megacolon), as well as exclusion of Clostridium difficile and…