Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 29: Medical Therapy of Left-Sided Ulcerative Colitis (continued)

Douglas B. Haghighi, DMD, MD; Bret A. Lashner, MD, MPH

MEDICAL THERAPY OF LEFT-SIDED ULCERATIVE COLITIS Left-sided ulcerative colitis (UC) is not a distinct entity, but a less extensive form of pancolitis. Therefore, the epidemiologic and genetic characteristics are thought to be analogous. However, the rate of colorectal cancer seems to be proportional to the extent of disease. The primary treatment that has been used for left-sided disease is topical 5-ASA agents. In patients who do not respond to topical therapy, oral 5-ASA agents of differing delivery methods to the distal bowel can be used. There is much debate pertaining to the clinical…