Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 25: Novel Nonbiological Therapy for Ulcerative Colitis (continued)

William J. Sandborn, MD

NOVEL NONBIOLOGIC THERAPY FOR ULCERATIVE COLITIS A variety of novel nonbiologic treatments have been evaluated for the medical treatment of patients with ulcerative colitis. This chapter will review the results from clinical trials that assessed the efficacy of novel nonbiologic medications for this treatment indication. Mycophenolate mofetil is an ester prodrug of mycophenolic acid, the active moiety that gives the drug its immunosuppressive properties.1 Mycophenolic acid decreases de-novo synthesis of guanosine nucleotides by reversible inhibition of inosine monophosphate dehydrogenase…