Probiotics: A Clinical Guide

Martin H. Floch, MD; Adam S. Kim, MD

Chapter 4: Probiotics And The Allergic Response (continued)

Erika Isolauri, MD, PhD; Samuli rautava, MD, PhD; Kirsi Laitinen, PhD; Seppo Salminen, PhD

Allergic responses are characterized by the generation of T helper (Th) cell 2-type cytokines, including interleukin (IL)-4, IL-5, and IL-13, which promote IgE production and eosinophilia recruitment. Early events in the immunologic activation promote the generation of these cytokines. The Th2-skewed immune type may be balanced by cytokines secreted by Th1, Th3, and Tr1 cells, partially as a result of stimulation by the gut microbiota.1 Allergic response, however, is not limited to IgE-associated immunologic processes,2 which, again, are not directly causally linked to a clinical allergic…