Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 28: Pre- and Probiotics in Crohn’s Disease (continued)

Robert M. Penner, BSc, MD, FRCP(C), MSc; Karen L. Madsen, PhD; Richard N. Fedorak, MD, FRCP(C)

As will be seen in Chapter 33, probiotics have been promising in the management of ulcerative colitis-related inflammation, particularly in the setting of pouchitis. Intuitively, CD might offer an even more advantageous setting for the use of probiotics, since the intestinal luminal bacterial population in CD has been previously found to differ more from normal subjects than that of ulcerative colitis, with the affected terminal ileum harboring an even more concentrated population of pathogenic bacteria and a markedly diminished population of probiotic bacteria than seen in ulcerative…