Probiotics: A Clinical Guide

Martin H. Floch, MD; Adam S. Kim, MD

Chapter 7: Fermentation And The Effects Of Probiotics On Host Metabolism (continued)

George T. Macfarlane, BSc, PhD; Sandra Macfarlane, BSc, PhD; Katie L. Blackett, BSc, PhD

The large intestinal microbiota interacts with the human host in multiple ways and plays a key role in many physiologic processes, such as vitamin formation, protection from invading pathogens, bile acid and steroid transformations, metabolism of xenobiotic compounds, mineral absorption, and immune system development and function. The microbiota also participates in the activation and destruction of toxins, genotoxins, and mutagens. The metabolic activities of intestinal microorganisms therefore play a key role in host physiology in both health and disease.1 Colonic bacteria are responsible…