Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 10: Acid-Peptic Disorders (continued)

Thomas O. G. Kovacs, MD

Peptic ulcer disease (PUD) occurs commonly and is an important cause of morbidity and health care costs. Although the incidence of PUD has decreased over the past decade (yearly incidence of 5 cases per 1000 people), the rates of hospitalization and deaths from ulcer complications have been relatively stable over that same time. A peptic ulcer is a defect in the gastric or duodenal wall that extends through the muscularis mucosa (the deepest limit of the mucosa) into the submucosa or muscularis propria. The gastric lumen pH is about 1, while the gastric mucosal barrier maintains a pH of…