Curbside Consultation of the Colon: 49 Clinical Questions

Brooks D. Cash, MD, FACP, CDR, MC, USN

Question 45: What Are The Adverse Effects Of Nonsteroidal Anti-Inflammatory Drugs On The Colon And How Can They Be Mitigated? (continued)

Scott L. Itzkowitz, DO, FACP

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most common classes of drugs taken by patients. Aside from the effects seen in the upper gastrointestinal tract (most notably the development of erosions or frank peptic ulcer disease), there are also several less well-known adverse effects in the colon. It could be argued that the increased use of enteric-coated or sustained-release preparations, in an attempt to decrease the gastroduodenal side effects of this class of medications, has shifted the potential for adverse events secondary to NSAIDs to the distal small intestine and…