Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 26: Which Patients With Cholangiocarcinoma Are Candidates For Surgical Resection? Is Liver Transplant An Option For Patients With Cholangiocarcinoma? (continued)

William R. Hutson, MD

Cholangiocarcinoma is an uncommon cancer and accounts for about 3% of all gastrointestinal malignancies and 10% of all primary liver cancers. The reported incidence is 1 to 2 cases per 100,000 population. Men and women are equally affected, and the majority of patients are older than 65 years. Cholangiocarcinoma is rarely associated with cirrhosis. Many patients with cholangiocarcinoma have no risk factors, but there are several conditions associated with an increased incidence. Those conditions are usually associated with proliferative changes or dysplasia of the bile duct epithelium. The…