Curbside Consultation in Endoscopy: 49 Clinical Questions, Second Edition

Joseph Leung, MD; Simon Lo, MD

Question 12: A 38-Year-Old Mildly Obese Female Presented With Gerd Symptoms And Was Found To Have A Persistently Elevated Amylase Level Around 250 Iu/L (Normal < 125) But Normal Lipase. How Should I Manage This Patient? (continued)

Sooraj Tejaswi, MD, MSPH

Amylase is a digestive enzyme mainly derived from the pancreas (isoform P) and the salivary glands (isoform S), but it can be found in other tissues in smaller quantities. Its main function is digestion of starch, as suggested by its Greek origin amylone, meaning starch. Amylase is a small molecule that is easily filtered by the renal glomeruli, and approximately 25% of it is excreted through the kidneys. The majority (75%) is excreted through the reticuloendothelial system. Serum amylase should be checked in the clinical setting for patients presenting with abdominal pain and…