Curbside Consultation of the Pancreas: 49 Clinical Questions

Scott Tenner, MD, MPH; Alphonso Brown, MD, MS Clin Epi; Frank Gress, MD

Question 33: What Are The Treatment Options For Early And Locally Advanced Pancreatic Cancer? (continued)

Paul S. Sepe, MD

Pancreatic cancer is the 4th leading cause of cancer death in the United States. In 2006, there were approximately 33,730 new cases with 32,300 deaths. Worldwide, incidence is approximately 217,000 new cases per year with 213,000 deaths. The lethality of pancreatic cancer stems largely from the fact that less than 20% of patients present with potentially resectable disease. While management of metastatic disease focuses mainly on palliation of symptoms and prolonging survival, the optimal therapy for early and locally advanced pancreatic cancer remains controversial and is currently the…