Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 36: Which Diseases Increase The Risk Of Developing Small Bowel Carcinoma? (continued)

Caroline R. Tadros, MD

Despite the fact that the small intestine comprises 75% of the gastrointestinal (GI) tract, small intestinal neoplasms only account for 1% to 2% of all GI malignancies. Approximately two-thirds of these neoplasms are malignant. It has been hypothesized that this low rate of malignancy is due to a combination of the following: • The rapid transit time of luminal contents within the small bowel (decreases mucosal contact with potential carcinogens) • The low bacterial count • Rapid epithelial cell turnover (leads to shedding of mutation-carrying cells) • Local…