Curbside Consultation of the Colon: 49 Clinical Questions

Brooks D. Cash, MD, FACP, CDR, MC, USN

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Question 11: My Patient Was Found To Have About 50 Hyperplastic Polyps Ranging From 5 To 15 Mm. What Condition Do I Need To Think About And How Should I Manage This Patient? (continued)

Christopher S. Huang, MD; Francis A. Farraye, MD, MSc; Michael J. O'Brien, MD, MPH

Your patient likely has a rare condition known as hyperplastic polyposis syndrome, or HPS. The World Health Organization has established the following criteria for the diagnosis of HPS1: (1) at least 5 hyperplastic polyps located proximal to the sigmoid colon, of which 2 are larger than 10 mm in diameter; or (2) any number of hyperplastic polyps located proximal to the sigmoid colon in an individual who has a first-degree relative with HPS; or (3) more than 30 hyperplastic polyps of any size, distributed throughout the colon. It should be noted that these criteria are somewhat arbitrary, and…