Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 8: What Is The Relationship Between Helicobacter Pylori And The Development Of Gastric Cancer And Lymphoma? Do All Patients With Helicobacter Pylori-Related Gastric Malignancies Need Surgery? (continued)

Scott Pollack, MD; Virendra Joshi, MD, AGAF

Helicobacter pylori infection is found in approximately half of the world’s population and has been shown to be involved in several gastroduodenal diseases, namely peptic ulcer disease, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. Most individuals who are infected with H. pylori remain asymptomatic throughout life. H. pylori has been deemed a class I carcinogen by the World Health Organization (WHO), and there are several mechanisms by which this gram-negative bacterium has been implicated in the pathologic changes leading to dysplasia and malignancy. Gastric…