Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 47: Which Patients With Rectal Cancer Should Undergo Neoadjuvant Therapy And Which Patients Can Proceed Directly To Surgery? (continued)

Ryan C. Van Woerkom, MD; Douglas G. Adler, MD, FACG, AGAF, FASGE

Colorectal cancer (CRC) is the third leading cause of death in the United States of men and women. The rectum lies between the anogenital ring and extends into the rectosigmoid junction. Adenocarcinoma developing at the distal 12 to 15 cm of the colon is typically depicted as rectal cancer. As defined, 40,870 Americans will develop rectal cancer (RC) according to the American Cancer Society’s newest estimated incidence in 2009 for the United States.1,2 Advancing age, a family history of CRC or polyps, a personal history of inflammatory bowel disease, pelvic radiation therapy, or…