Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 12: What Is Linitis Plastica, And How Does Its Development Affect The Management And Prognosis Of Patients With Gastric Cancer? (continued)

Caroline R. Tadros, MD

Linitis plastica (LP) refers to anaplastic carcinoma that is characterized by diffuse intramural infiltration. This results in wall thickening and decreased volume of a hollow viscous. It can occur throughout the gastrointestinal (GI) tract; however, the stomach is the most commonly affected organ.1,2 It has been reported to occur in 3% to 19% of all gastric carcinomas1 (Figure 12-1). LP typically arises from the lower third of the mucosa and is associated with an extensive desmoplastic reaction in the submucosa.1 Fibrosis can also be found within the subserosa…