Curbside Consultation of the Liver: 49 Clinical Questions

Mitchell L. Shiffman, MD

Question 28: What Is The Best Treatment To Utilize In A Patient With Fatty Liver Disease And Type 2 Diabetes Mellitus? (continued)

Arun J. Sanyal, MD; Puneet Puri, MD

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in the United States.1 NAFLD includes a nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). NASH can progress to cirrhosis in up to 15% of subjects. NAFLD is associated with abdominal obesity, type 2 diabetes, hypertension, and dyslipidemia, together known as the metabolic syndrome, which is characterized by the presence of insulin resistance. The main focus of management is to treat the risk factors for NAFLD. The presence of obesity and T2DM independently influences the severity of…