Guide to Alternative Medicine and the Digestive System

Anil Minocha, MD FACP FACG

Chapter 10: Leaky Gut: Fact or Fiction? (continued)

KEY POINTS The human body is constantly being subjected to a barrage of chemical, physical, and biological insults from the gastrointestinal (GI) lumen. The body is protected by the so-called intestinal barrier.1 The epithelial barrier is highly selective and semipermeable. It is a complex, dense mucous layer composed of IgA, antimicrobial peptides, and junctional complexes, including tight junctions (TJs). Intestinal epithelium safeguards the mucosal barrier immunity.2