GI and Liver Disease During Pregnancy: A Practical Approach

Kim L Isaacs, MD PhD; Millie D Long, MD MPH

Chapter 11: Chronic Liver Disease (continued)

Caitlyn M. Patrick, MD; A. Sidney Barritt IV, MD, MSCR

Pregnancy in the setting of chronic liver disease is rare for several reasons. First, most women with advanced liver disease tend to be in their postreproductive years, with one study finding the prevalence of cirrhosis in reproductive-aged women to be approximately 45 cases per 100,000. Second, if the liver disease does progress earlier in these patients, they are typically infertile due to hormonal alterations caused by their liver disease that result in anovulation and amenorrhea.1 Furthermore, there has historically been a high rate of maternal mortality in these patients as high as…