Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 42: Fulminant Liver Failure And Transplantation (continued)

John P. Duffy, MD

Fulminant hepatic failure (FHF) is a clinical syndrome consisting of jaundice, encephalopathy, and coagulopathy in patients without history of liver dysfunction. It is an aggressive disease process requiring intensive care therapeutics and, often, urgent liver transplantation (LT) as a life-saving measure. The overall mortality rate for patients presenting with FHF nears 50%, and FHF now accounts for about 5% of all LTs performed. Clinicians must be familiar with FHF to implement rapid therapy and to initiate early transfer to a LT center for supportive care, transplant evaluation, and liver…