Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 35: Nonalcoholic Fatty Liver Disease (continued)

Michel H. Mendler, MD, MS

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the United States. It is associated with insulin resistance and, in most instances, is a benign condition. However, it can progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma (HCC). Secondary fatty liver disease is due to either liver diseases, such as alcoholic liver disease, viral hepatitis, autoimmune hepatitis, and Wilson’s disease, or nonhepatic processes, such as drug-induced steatosis (amiodarone), jejunal bypass, protein malnutrition, or rare…