Common Liver Diseases and Transplantation: An Algorithmic Approach to Work Up and Management

Robert S Brown Jr, MD MPH

Chapter 9: Autoimmune And Cholestatic Diseases (continued)

Patrick Basu, MD, MRCP, AGAF; Niraj James Shah, MD

Despite progress in the diagnosis and management of patients with autoimmune and cholestatic diseases of the liver, these diseases continue to represent areas of significant unmet medical need. While slow to progress, untreated primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) in a significant proportion of patients will ultimately develop into cirrhosis and associated complications and may necessitate liver transplantation in late stages.1,2 Autoimmune hepatitis (AIH), though frequently treatable if diagnosed early, can progress to cirrhosis or have acute flares with…