Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 33: In Nonsurgical Patients With Hepatocellular Cancer, What Treatment Options Exist, And How Effective Are They? (continued)

Allene Salcedo Burdette, MD

Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and the eighth most common in women worldwide. Almost 600,000 new cases of HCC are diagnosed annually worldwide. Without therapy, the median length of survival is 6 months, and 5-year survival is a dismal 5%. Transplantation or resection results in the longest survival, but fewer than 20% of patients with HCC are surgical candidates.1,2 Several options for liver-directed therapy are available to nonsurgical HCC patients. Because of variation between patients, one treatment is not ideal for all. The method of treatment…