Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 32: Abnormal Liver Function Tests (continued)

Simon W. Beaven, MD, PhD

Elevated liver function tests (LFTs; ie, aspartate aminotransferase/serum glutamic oxaloacetic transaminase [AST/SGOT], alanine aminotransferase/serum glutamic pyruvic transaminase [ALT/SPGT], total bilirubin, and alkaline phosphatase) are a common occurrence in clinical practice. Fortunately, the cause can usually be determined by a careful history and physical examination. With a sudden, marked elevation, or where no obvious risk factor is established, a liver biopsy should be considered. Initial evaluation emphasizes the chronicity (Figure 32-1) and absolute degree of elevation and…