Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 38: Cholestatic Liver Diseases (continued)

Francisco Antonio Durazo, MD, FACP

Primary biliary cirrhosis (PBC) is characterized by chronic, nonsuppurative cholangitis affecting the interlobular and septal bile ducts. One unique feature is the high degree of specificity for involvement of the small intrahepatic ducts. The etiology of PBC is thought to be a combination of genetic predisposition and environmental triggers. Its clinical course can behave as a chronic cholestatic disease with a progressive course or may last many decades. The overall survival in patients treated with ursodeoxycholic acid (UDCA) without liver transplantation (OLT) is 84% at 10 years and 66%…