Curbside Consultation of the Liver: 49 Clinical Questions

Mitchell L. Shiffman, MD

Question 20: How Frequently Should I Have A Patient With Genetic Hemochromatosis Undergo Phlebotomy? (continued)

Peter Dienhart, MD; Jayanta Choudhury, MD; Anastasios A. Mihas, MD, DMSc, FACP, FACG

Hereditary hemochromatosis (HH) is one of the most common inherited causes of chronic liver disease, whose effects on target organs are preventable if detected early. Thus, the goal of treatment is the prevention of iron deposition in target organs as well as early treatment of its complications. Once the diagnosis is established, the therapeutic options are simple, effective, and relatively inexpensive. The most effective available therapeutic option to manage iron overload is phlebotomy.1 It should be initiated in patients who are homozygous to the C282Y mutation, compound heterozygotes…